nucleotides – Communicable Diseases Research

Analysis of the mutation dynamics of SARS-CoV-2 genome in the samples from Georgia State of the United States

미국 조지아주 샘플에서 SARS-CoV-2 게놈의 돌연변이 역학 분석

Article

Published on 2022-10-202022-09-11
Journal: Gene
[Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Algorithm Amino acid Analysis analysis caused China clade clades Complete coronavirus disease Coronavirus disease 2019 Coronavirus-2 country Course COVID-19 D614G determine disease England Europe Filter Genome genome sequence Genome sequences Host indicate limit majority Multiple Multiple studies mutated Mutation N501Y NCBI database Novel coronavirus novel coronavirus SARS-CoV-2 nucleotide nucleotides online tool over P681H pandemic Phylogenetic Quality control reference genome SARS-CoV-2 SARS-CoV-2 genome SARS-CoV2 sequence Sequence alignment sequenced genomes sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe acute respiratory syndrome coronavirus-2. Spread state survival the United State the WHO translation Transmission variant variants virus was used Wuhan
[DOI] 10.1016/j.gene.2022.146774 PMC 바로가기 [Article Type] Article

ATP enhances the error-prone ribonucleotide incorporation by the SARS-CoV-2 RNA polymerase

Article

Published on 2022-10-152022-11-15
Journal: Biochemical and Biophysical Research Communication
[Category] COVID19(2023년), SARS, 치료제,

Artificially expanded genetic information systems (AEGISs) as potent inhibitors of the RNA-dependent RNA polymerase of the SARS-CoV-2

SARS-CoV-2의 RNA 의존성 RNA 중합효소의 강력한 억제제로서 인공적으로 확장된 유전 정보 시스템(AEGIS)

Article

Published on 2022-09-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] SARS, 유전자 메커니즘, 치료제,

[키워드] AEGIS affected Antiviral agents antiviral agents. binding binding site candidate COVID-19 drug Economy examined genetic information help host cells identify in vivo Infection Information Systems inhibit inhibitor ligands MD simulations mechanism molecular docking monophosphate nucleotide nucleotides Original position outbreak pandemic potential therapeutic agent potential therapeutic agents RdRP RDV Remdesivir Replication responsible RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection sequence shown the SARS-CoV-2 therapeutic toxicities Toxicity Transmission unavailability Viral RNA virus
[DOI] 10.1080/07391102.2021.1883112 PMC 바로가기 [Article Type] Article

Covid-19, an unfinished story

Mini review

Published on 2022-09-012022-10-05
Journal: La Presse Médicale
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] activities acute respiratory distress age amplitude bat coronavirus Beta Betacoronavirus caused China Cluster Comorbidities compulsory vaccination condition confirmed case coronavirus COVID-19 Critical cross deaths degree Delta detect development drug effective Efficacy epidemic waves epidemiological surveillance evade Face mask FIVE form Gamma Genome genomic Health highly pathogenic homogeneity Host Human immune response Immunity incidence rate include Inflammatory Innovation intensive care Measures Messenger RNA mild infection Moderna mRNA vaccine multiorgan failure nucleotides occupancy rate omicron Oxygen therapy pandemic Patient Pfizer-BioNTech Pneumonia preventing the transmission progressed Protective replaced RNA SARS-CoV-2 SARS-CoV-2 vaccine Sequencing severity syndrome the WHO thromboembolic complications Vaccine Vaccines variant variants variants of concern viral invasion VoC WHO World Health Organization
[DOI] 10.1016/j.lpm.2022.104131 [Article Type] Mini review

SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNA

SARS-CoV-2 nsp14 엑소리보뉴클레아제는 RNA에서 천연 항바이러스성 3'-데옥시-3',4'-디데하이드로-시티딘 뉴클레오타이드를 제거합니다

Article

Published on 2022-08-162022-09-11
Journal: Viruses
[Category] SARS, 변종, 유전자 메커니즘, 치료제,

A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA Polymerase

SARS-CoV-2 RNA 의존성 RNA 중합효소의 최적 뉴클레오티드 유사체 농도 및 속도 제한 뉴클레오티드에 대한 체계적인 연구

Article

Published on 2022-07-272022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 치료제,

Identifying SARS-CoV-2 Variants of Concern through Saliva-Based RT-qPCR by Targeting Recurrent Mutation Sites

재발 돌연변이 부위를 표적으로 하여 타액 기반 RT-qPCR을 통해 우려의 SARS-CoV-2 변이체 식별

Article

Published on 2022-06-292022-09-11
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

[키워드] Accuracy antibody approach characterized clinical methods complement concern COVID-19 demonstrated diagnostic diagnostics E484K Efficacy Genetic identify identifying influence investigated L452R Mask mandates Mutation nucleotides omicron performed Population screening positive probe public health public health threat qPCR qPCR assays quarantine Real-time monitoring recommendation Recurrent RNA RT-qPCR RT-qPCR assay Saliva saliva samples SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variant SARS-CoV-2 variants screened selective Sequencing single nucleotide Site SNP South Spread Surveillance targeting Transmissibility treatment regimens variants variants of concern variants of concern. VoC VOCs whole genome whole genome sequence Whole genome sequencing
[DOI] 10.1128/spectrum.00797-22 PMC 바로가기 [Article Type] Article

Identifying Structural Features of Nucleotide Analogues to Overcome SARS-CoV-2 Exonuclease Activity

SARS-CoV-2 엑소뉴클레아제 활성을 극복하기 위한 뉴클레오티드 유사체의 구조적 특징 확인

Article

Published on 2022-06-282022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종, 치료제,

Repurposing benzbromarone as antifolate to develop novel antifungal therapy for Candida albicans

벤즈브로마론을 항엽산으로 용도 변경하여 칸디다 알비칸스에 대한 새로운 항진균 요법 개발

Article

Published on 2022-06-182022-09-11
Journal: Journal of molecular modeling
[Category] 신약개발,

[키워드] Absorption Antifungal antifungal therapy approach Benzbromarone Biosynthesis Candida Candida albican Candida albicans candidiasis coenzyme complex complications Computational drug COVID-19 COVID-19 patient COVID-19 patients develop DHFR dihydrofolate drug resistance Effect enzyme folate Folic acid followed by fungal Fungal infection fungal infections Human identify Immunocompromised Infection inhibitor involved macromolecular Mild molecular molecular docking Mortality nucleotides Probability problem problems repurposing required responsible resulting Severe infection severe infections symptomatic systemic effect systemic effects tetrahydrofolate therapy toxic effects Treatment Virtual screening White-fungus.
[DOI] 10.1007/s00894-022-05185-w PMC 바로가기 [Article Type] Article

Characterization of SARS-CoV-2 replication complex elongation and proofreading activity

SARS-CoV-2 복제 복합체 신장 및 교정 활성의 특성화

Article

Published on 2022-06-102022-09-11
Journal: Scientific Reports
[Category] COVID19(2023년), SARS, 치료제,